Our efforts center around combination therapy and chemoresistance, with the following topics:
1) non-genetic mechanisms of chemoresistance
2) roles of proteostasis in cancer therapeutics.
In addition to mechanistic studies, we also combine cancer biology with physical sciences to develop novel approaches to study tumorigenesis. For example, in collaboration with Dr. Susan Weintraub at UTH San Antonio, we have integrated BONCAT bioorthogonal chemistry with DIA-MS proteomics to decode proteostasis of tumor cells and remodeling of the tumor microenvironment.